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KMID : 1103720120670030177
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Journal of the Korean Society of Radiology
2012 Volume.67 No. 3 p.177 ~ p.186
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The Predictability for the Prognosis of Breast Cancer Using the Apparent Diffusion Coefficient Value of Diffusion-Weighted 3 T MRI and the Standardized Uptake Value of Positron Emission Tomography/CT: Assessment of Prognostic Factor
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Lim Seong-Joo
Kim Keum-Won
Jang Hye-Young
Hwang Cheol-Mok
Kim Dae-Ho
Sohn Jang-Shin
Kim Jin-Suk
Lee Jin-Yong
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Abstract
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Purpose: To correlate the apparent diffusion coefficient (ADC) value and peak standardized uptake value (pSUV) with histologic grade and clinical prognostic factors of breast ductal carcinoma.
Materials and Methods: Fifty breast cancers of 49 patients (age range: 37-83 years, mean: 53 years) were studied retrospectively. The breast cancers included 4 ductal carcinoma in situ (DCIS) and 46 invasive ductal carcinomas (IDC). The relationships for both pSUV and ADC values with clinicopathological prognostic factors (age, tumor size, histologic grade, nodal metastasis, hormone receptor and HER-2 neu status) were statistically evaluated.
Results: The histologic type of ductal carcinoma include DCIS (n = 4) and IDC (n = 46, grade 1 = 10, grade 2 = 13, and grade 3 = 23). pSUV was associated with histologic grade and tumor size and the ADC value was associated with histologic grade (p < 0.05). As the histologic grade becomes higher, the ADC values decrease, while pSUV and pSUV/ADC increase (p < 0.05). The characterization accuracy of pSUV/ADC (90.2%) was higher than pSUV (86.7%) and ADC values (25.4%) alone for the diagnosis of breast cancer (p < 0.05).
Conclusion: pSUV and ADC values correlated with histologic grade, and tumor size. The pSUV/ADC value had a high accuracy for the diagnosis of breast cancer. Therefore, pSUV and ADC values provided additional information for predicting histologic grade and prognosis of breast cancer
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KEYWORD
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Breast Cancer, MRI, Diffusion-Weight Image, Positron Emission Tomography/CT, Peak Standardized Uptake Value, Apparent Diffusion Coefficient
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